Oligostatins, new antibiotics with amylase inhibitory activity. I. Production, isolation and characterization.
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Oligostatins, new antibiotics with amylase inhibitory activity. I. Production, isolation and characterization.
Oligostatins C, D and E, three new antibiotics were found in the culture filtrate of Streptomyces myxogenes nov. sp. SF-1130. Their spectral and chemical properties suggested that oligostatins were basic oligosaccharide antibiotics. They exhibited not only antibacterial activity but also strong amylase inhibitory activity.
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Structure of Oligostatin C Oligostatin C (Ic), a basic, water-soluble, amorphous substance; m.p. 183'C (dec.), [a]21+154' (c 1, H,O), shows strong IR absorption maxima at 31003600 and 9801180 cm-1 indicative of its oligosaccharide nature. PMR spectrum of Ic in D2O shows a methyl signal at 1.38 ppm (d, J=6 Hz), a methine proton at 2.76 ppm (t, J=9 Hz) and complex signals at 5.2 5.5 ppm assignabl...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1981
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.34.1424